Vincenzo Carnevale
Ion channels response in physiological conditions: toward a computational framework for nociception
(baeg)Jun 2018 - Aug 2018
2018
Vincenzo Carnevale (2018): Protonation Underlies Tonic vs. Use-Dependent Block, Proceedings of the National Academy of Sciences, The National Academy of Sciences, Vol 115, Num 14, pp3512-3514
Marina A. Kasimova, Aysenur Yazici, Yevgen Yudin, Daniele Granata, Michael L. Klein, Tibor Rohacs, and Vincenzo Carnevale (2018): Ion Channel Sensing: Are Fluctuations the Crux of the Matter?, Journal of Physical Chemistry Letters, American Chemical Society, Vol 9, Num 6, pp1260-1264
Marina A. Kasimova, Aysenur Torun Yazici, Yevgen Yudin, Daniele Granata, Michael L. Klein, Tibor Rohacs, and Vincenzo Carnevale (2018): A hypothetical molecular mechanism for TRPV1 activation that invokes rotation of an S6 asparagine, Journal of General Physiology, Rockefeller University Press, Vol 150, Num 11, pp1554-1566
2017
Ximena Steinberg, Marina A. Kasimova, Deny Cabezas-Bratesco, Jason D. Galpin, Ernesto Ladron-de-Guevara, Federica Villa, Vincenzo Carnevale, Leon Islas, Christopher A. Ahern, and Sebastian E. Brauchi (2017): Conformational Dynamics in TRPV1 Channels Reported by an Encoded Coumarin Amino Acid, eLife, eLife Sciences Organisation, Ltd., Vol 6
Vincenzo Carnevale and Michael L Klein (2017): Small Molecule Modulation of Voltage Gated Sodium Channels, Current Opinion in Structural Biology, Elsevier BV, Vol 43, pp156-162
Daniele Granata, Luca Ponzoni, Cristian Micheletti, and Vincenzo Carnevale (2017): Patterns of Coevolving Amino Acids Unveil Structural and Dynamical Domains, Proceedings of the National Academy of Sciences, The National Academy of Sciences, Vol 114, Num 50, ppE10612-E10621
Asghar M. Razavi, Lucie Delemotte, Joshua R. Berlin, Vincenzo Carnevale, and Vincent A. Voelz (2017): Molecular Simulations and Free-Energy Calculations Suggest Conformation-Dependent Anion Binding to a Cytoplasmic Site as a Mechanism for Na+/K+-ATPase Ion Selectivity, Journal of Biological Chemistry, American Society for Biochemistry & Molecular Biology, Vol 292, Num 30, pp12412-12423
2016
Khaled Elokely, Phanindra Velisetty, Lucie Delemotte, Eugene Palovcak, Michael L. Klein, Tibor Rohacs, and Vincenzo Carnevale (2016): Understanding TRPV1 Activation by Ligands: Insights from the Binding Modes of Capsaicin and Resiniferatoxin, Proceedings of the National Academy of Sciences, National Academy of Sciences, Vol 113, Num 2, ppE137-E145
2015
Eugene Palovcak, Lucie Delemotte, Michael L. Klein, and Vincenzo Carnevale (2015): Comparative Sequence Analysis Suggests a Conserved Gating Mechanism for TRP Channels, Journal of General Physiology, Rockefeller University Press, Vol 146, Num 1, pp37-50
Luca Ponzoni, Guido Polles, Vincenzo Carnevale, and Cristian Micheletti (2015): SPECTRUS: A Dimensionality Reduction Approach for Identifying Dynamical Domains in Protein Complexes from Limited Structural Datasets, Structure, Elsevier BV, Vol 23, Num 8, pp1516-1525
2018
Vincenzo Carnevale, Michael Klein, Giacomo Fiorin, Tibor Rohacs (2018): Molecular Dynamics Simulations Unveil the Mechanism of the Sensitivity to Heat of an Ion Channel, 2018 Blue Waters Annual Report, pp210-211
2017
Vincenzo Carnevale (2017): Mechanism of Temperature Sensitivity in TRPV1 Channel, 2017 Blue Waters Annual Report, pp202-203
Eleonora Gianti: TRPA1 as a Drug Target for the Treatment of Chronic Pain
Blue Waters Symposium 2017, May 16, 2017
Blue Waters Symposium 2017, May 16, 2017
Better understanding of voltage-gated-like ion channels may spark improvements in general anesthesia
Mar 16, 2016
Up until recently, there has been very little understanding on how exactly general anesthesia worked. Vincenzo Carnevale, Research Associate Professor at Temple University in Pennsylvania, is part of a team of researchers who is trying to do just that by understanding the functional mechanisms of voltage-gated-like ion channels.
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NSF awards time on Blue Waters to seven new projects
Oct 1, 2014
The National Science Foundation (NSF) has awarded 14 new allocations on the Blue Waters petascale supercomputer at the National Center for Supercomputing Applications (NCSA) at the University of Illinois at Urbana-Champaign. Seven of the awards are for new projects.
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