Nilufer Ertekin-Taner

2020

D. P. Wickland, Y. Ren, J. P. Sinnwell, J. S. Reddy, C. Pottier, V. Sarangi, S. Tian, S. G. Younkin, M. M. Carasquillo, O. A. Ross, S. G. Younkin, N. Ertekin-Taner, R. Rademakers, M. E. Hudson, L. S. Mainzer, J.M. Biernacka, and Y. W. Asman (2020): Impact of variant-level hidden batch effects on identification of genetic risk factors in large sequencing studies, (submitted)

2018

Yingxue Ren, Joseph S. Reddy, Cyril Pottier, Vivekananda Sarangi, Shulan Tian, Jason P. Sinnwell, Shannon K. McDonnell, Joanna M. Biernacka, Minerva M. Carrasquillo, Owen A. Ross, Nilüfer Ertekin-Taner, Rosa Rademakers, Matthew Hudson, Liudmila Sergeevna Mainzer, and Yan W. Asmann (2018): Identification of Missing Variants by Combining Multiple Analytic Pipelines, BMC Bioinformatics, Springer Nature, Vol 19, Num 1, pp139

2015

Nilufer Ertekin-Taner (2015): Epistatic Interactions for Brain Expression GWAS in Alzheimer's Disease, 2015 Blue Waters Annual Report, pp134-135

Five fast facts you should know about Alzheimer’s research on the Blue Waters supercomputer


Apr 27, 2016

Mariet Allen is an assistant professor of neuroscience at Mayo Clinic in Florida, and is conducting ongoing research using the Blue Waters supercomputer at the National Center for Supercomputing Applications (NCSA) at the University of Illinois to understand the role that genetics plays in Alzheimer’s disease. Considering that the research is examining pairs of variants instead of individual variants, running these analyses are computationally intensive. Because of that, Allen collaborated with investigators at the University of Illinois at Urbana-Champaign, receiving support from NCSA and the Mayo Clinic in order to run the analysis that was not possible without a supercomputer. "It's not like the kind of analysis that can be done routinely, in most university institutions," Allen says. "That's where Blue Waters really came in and enabled us to do the analysis."


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Uncovering Alzheimer's complex genetic networks


Feb 3, 2015

The release of the film, "Still Alice," in September 2014 shone a much-needed light on Alzheimer's disease, a debilitating neurological disease that affects a growing number of Americans each year. ... "We re interested in studying the genetics of Alzheimer's disease," said Mariet Allen, a post-doctoral fellow at the Mayo Clinic in Florida. "Can we identify genetic risk factors and improve our understanding of the biological pathways and cellular mechanisms that can play a role in the disease process?" Allen is part of a team of researchers from the Mayo Clinic who are using Blue Waters, one of the most powerful supercomputers in the world, to decode the complicated language of genetic pathways in the brain. In doing so, they hope to provide insights into what genes and proteins are malfunctioning in the brain, causing amyloid beta plaques, tau protein tangles and brain atrophy due to neuronal cell loss--the telltale signs of the disease--and how these genes can be detected and addressed.


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