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Jodi Hadden

2020

Zhongchao Zhao, Joseph Che-Yen Wang, Carolina Perez-Segura, Jodi A. Hadden-Perilla, and Adam Zlotnick (2020): The integrity of the intradimer interface of the Hepatitis B Virus capsid protein dimer regulates capsid self-assembly, ACS Chemical Biology, American Chemical Society, Vol 15, Num 12, pp3124-3132

2019

Alexander J. Bryer, Jodi A. Hadden-Perilla, John E. Stone, and Juan R. Perilla (2019): High-Performance Analysis of Biomolecular Containers to Measure Small-Molecule Transport, Transbilayer Lipid Diffusion, and Protein Cavities, Journal of Chemical Information and Modeling, American Chemical Society, Vol 59, Num 10, pp4328-4338

2018

Jodi A. Hadden, Juan R. Perilla, Christopher John Schlicksup, Balasubramanian Venkatakrishnan, Adam Zlotnick, and Klaus Schulten (2018): All-Atom Molecular Dynamics of the HBV Capsid Reveals Insights Into Biological Function and Cryo-EM Resolution Limits, eLife, eLife Sciences Organisation, Ltd., Vol 7
Lu Ruan, Jodi A. Hadden, and Adam Zlotnick (2018): Assembly Properties of Hepatitis B Virus Core Protein Mutants Correlate with Their Resistance to Assembly-Directed Antivirals, Journal of Virology, American Society for Microbiology, ppJVI.01082-18

2017

Lisa G. Lippert, Tali Dadosh, Jodi A. Hadden, Vishakha Karnawat, Benjamin T. Diroll, Christopher B. Murray, Erika L. F. Holzbaur, Klaus Schulten, Samara L. Reck-Peterson, and Yale E. Goldman (2017): Angular Measurements of the Dynein Ring Reveal a Stepping Mechanism Dependent on a Flexible Stalk, Proceedings of the National Academy of Sciences, National Academy of Sciences, Vol 114, Num 23, ppE4564-E4573

2016

Juan R. Perilla, Jodi A. Hadden, Boon Chong Goh, Christopher G. Mayne, and Klaus Schulten (2016): All-Atom Molecular Dynamics of Virus Capsids as Drug Targets, Journal of Physical Chemistry Letters, American Chemical Society, Vol 7, Num 10, pp1836-1844

2019

Jodi A. Hadden–Perilla, Adam Zlotnick, Juan R. Perilla, Michael F. Hagan, Brian Bothner (2019): Molecular Dynamics Simulations of the HBV Capsid, 2019 Blue Waters Annual Report, pp260-261
Jodi A. Hadden–Perilla, Adam Zlotnick, Juan R. Perilla, Michael F. Hagan, Brian Bothner (2019): Molecular Dynamics Simulations of the HBV Capsid as a Drug Target, 2019 Blue Waters Annual Report, pp262-263

How a Virus Assembles


Aug 11, 2020

Researchers at the University of Delaware, using supercomputing resources and collaborating with scientists at Indiana University, have gained new understanding of the virus that causes hepatitis B and the “spiky ball” that encloses the virus’s genetic blueprint.


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Biophysics on World Hepatitis Day


Jul 28, 2018

July 28 is World Hepatitis Day. We spoke with Biophysical Society members whose research focuses on viruses, including hepatitis B. Hepatitis B is a potentially life-threatening liver infection caused by the hepatitis B virus (HBV). It can cause chronic infection and puts people at high risk of death from cirrhosis and liver cancer. According to the World Health Organization, an estimated 257 million people are living with hepatitis B virus infection. In recognition of World Hepatitis Day, Jodi A. Hadden and Juan R. Perilla, both University of Delaware, and JC Gumbart, Georgia Tech, filled us in on their research related to HBV.


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A view of a virus: research reveals new insights into hepatitis B


May 31, 2018

Researchers at the University of Delaware, working with colleagues at Indiana University, have gained new insights into the virus that causes hepatitis B — a life-threatening and incurable infection that afflicts more than 250 million people worldwide. The discovery, which was published April 27 in the journal eLife, reveals previously unknown details about the capsid, or protein shell, that encloses the virus’ genetic blueprint. Scientists believe that the capsid, which drives the delivery of that blueprint to infect a host cell, is a key target in developing drugs to treat hepatitis B. “With hepatitis B, the structure of the capsid has been known for years, but we wanted to study its motion and its influence on its surroundings,” said Jodi A. Hadden, an independent postdoctoral researcher in UD’s Department of Chemistry and Biochemistry and the lead author of the new paper.


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