Furthering characterization of the hepatitis B virus capsid as a drug target: Simulations to investigate quasi-equivalence and cooperativity in drug binding(baxb)
Jan 2019 - Dec 2019
Blue Waters Symposium 2019, Jun 5, 2019
Aug 11, 2020
Researchers at the University of Delaware, using supercomputing resources and collaborating with scientists at Indiana University, have gained new understanding of the virus that causes hepatitis B and the “spiky ball” that encloses the virus’s genetic blueprint.
Jul 28, 2018
July 28 is World Hepatitis Day. We spoke with Biophysical Society members whose research focuses on viruses, including hepatitis B. Hepatitis B is a potentially life-threatening liver infection caused by the hepatitis B virus (HBV). It can cause chronic infection and puts people at high risk of death from cirrhosis and liver cancer. According to the World Health Organization, an estimated 257 million people are living with hepatitis B virus infection. In recognition of World Hepatitis Day, Jodi A. Hadden and Juan R. Perilla, both University of Delaware, and JC Gumbart, Georgia Tech, filled us in on their research related to HBV.
May 31, 2018
Researchers at the University of Delaware, working with colleagues at Indiana University, have gained new insights into the virus that causes hepatitis B — a life-threatening and incurable infection that afflicts more than 250 million people worldwide. The discovery, which was published April 27 in the journal eLife, reveals previously unknown details about the capsid, or protein shell, that encloses the virus’ genetic blueprint. Scientists believe that the capsid, which drives the delivery of that blueprint to infect a host cell, is a key target in developing drugs to treat hepatitis B. “With hepatitis B, the structure of the capsid has been known for years, but we wanted to study its motion and its influence on its surroundings,” said Jodi A. Hadden, an independent postdoctoral researcher in UD’s Department of Chemistry and Biochemistry and the lead author of the new paper.