C. Crescentus Cell Division Using Our In-House Lattice Microbe Simulation Program AND Interactions Between Ribosomal Signatures and 5' and Central Domain of the Ribosomal Small Subunit Using NAMD 2.9 Accelerated by GPUs

Zaida Luthey-Schulten, University of Illinois at Urbana-Champaign

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Zaida Luthey-Schulten, Brian Jewett, Jonathan Lai, Ke Chen, Joseph Peterson, Piyush Labhsetwar, Michael Hallock, John Cole, Tyler Earnest, Marcelo Dos Reis Melo

Experiments are beginning to reveal connections between DNA transcription and replication with ribosomal assembly in bacteria. The first of two planned projects focuses on the dynamics and spatial heterogeneity of key regulators of chromosomal replication and cell-cycle timing. We will use our own GPU-accelerated Lattice Microbes software to perform stochastic simulations of the reaction models on the whole cell level. The second project focuses on the assembly of the pre-30S ribosomal complex. Molecular dynamics simulations of the ribosomal assembly process, using NAMD 2.9 accelerated by GPUs, will provide details of structural intermediates along the folding pathway which can be compared to in vitro and in vivo experiments.

http://www.scs.illinois.edu/schulten/research/index.html