Molecular Mechanism of DNA Exchange

Aleksei Aksimentiev, University of Illinois at Urbana-Champaign

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Aleksei Aksimentiev, Jejoong Yoo, Christopher Maffeo, Maxim Belkin, Manish Shankla, Shu-Han Chao, Chen-Yu Li, Karl Decker, Derek VanDamme, Gino Giannetti, James Wilson, Dmitrii Kochkov, Scott Michael Slone, Shalini Lovis, Alex Finnegan, David Winogradoff, Wei Si, Isaac Freund, John Zeiders

One of the most catastrophic forms of DNA damage is double-stranded DNA breakage, which is often repaired using, as a template, another DNA molecule of a similar nucleotide sequence. In living cells across all kingdoms of life, this repair process is mediated by specialized protein machinery that brings the damaged and template molecules of DNA together, facilitating a transfer of an intact DNA strand from the template molecule to the damaged one. In collaboration with the group of single molecule experimentalists, this project will determine the molecular mechanism of the key step of the DNA repair process: the transfer of a DNA strand from one DNA molecule to another.

http://bionano.physics.illinois.edu/