Accelerating magnetic resonance imaging based biomarker development through HPC

Brad Sutton, University of Illinois at Urbana-Champaign

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Alzheimer's disease (AD) currently costs over $800 billion and contributes to more than 500,000 deaths each year in the U.S. Studying the role of the microvasculature of the brain in the development of AD has been limited by the invasive and destructive techniques currently required to understand the longitudinal pathological changes involved in the development of AD. We have recently undertaken a study of 52 volunteers—30 young adults and 22 older adults—to validate a proposed imaging-based biomarker of the state of the microvasculature in the brain. In order to reconstruct the 5TB of data collected from the 52 subjects into images, we propose to use the Blue Waters supercomputer to perform GPU-accelerated advanced MRI reconstructions.