Novel Mechanism of Blood-Clotting Could Revolutionize Stroke and Heart Attack Treatments

Roman Voronov, New Jersey Institute of Technology

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Despite roughly $3 billion of annual expenditure on heart-attack and brain-stroke research, these diseases that are both caused by break-ups of blood clots, remain the 1st and 4th leading cause of death in the U.S., respectively (killing ~750k Americans every year). Our group is combining Nobel Laureate-developed Lattice Light Sheet Microscopy (available to only ~20 other labs in the world) with parallelized image-based Lattice Boltzmann Method computational fluid dynamics in order to investigate a novel mechanism of blood clot formation. The success of this project could lead to a novel class of anti-thrombotic drugs that could selectively dissolve just the dangerous part of the blood clot, while leaving the useful one intact. The student will be responsible for preprocessing the microscopy data, running/optimizing the LBM code, and post-processing/visualization of the computation results.