Amyloid formation in the presence of lipids

Ulrich Hansmann, University of Oklahoma

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Considerable evidence points to a role for membrane-associated production and propagation of oligomers in the progression of Alzheimer’s disease. An example for such lipid-catalyzed oligomers are the Large Fatty Acid-derived Aβ Oligomers (LFAOs) studied in the lab of our collaborator Vijay Rangachari (University of Southern Mississippi). However, neither the structure of LFAOs nor their mechanism of propagation is known in detail. Deriving both, and modeling their dependence on sequence and interfacial environment, will help us to understand the mechanism by which amyloid strains become predominant in patient brains.