Computational Researcher in Viral RNA Folding Team

Susan Schroeder, University of Oklahoma

Usage Details

The computational researcher will be an integral part of a team studying the ways that a viral RNA genome can fold into a virus particle. The Crumple, Sliding Windows, and Assembly computational tools can generate a combinatorially complete set of non-pseudoknotted RNA folds for a given sequence using constraints from cryo-electron microscopy and crystallography. Swellix computes all possible, non-pseudoknotted combinations of helices for a given sequence. Two stages of the Swellix program will be parallelized in order to increase the length of sequences that can be studied and more thoroughly explore conformational space for RNA.