Paracellular Transport Mechanism in Tight Junctions

Fatemeh Khalili-Araghi, University of Illinois at Chicago

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Claudins are one of the major components of tight junctions that control the permeability and selectivity of paracellular pores in endothelial cells. In contrast to canonical ion channels that form narrow pores in the lipid membrane, these pores are oriented parallel to the membrane and are formed by the assembly of multiple claudins in two parallel membranes. We will use molecular dynamics simulations to study the transport mechanism of small molecules through these pores.